If you have one task list for both work and home, and you can't afford an Exchange server or similar commercial solutions, then the best thing you can offer is to use the free Remember The Milk service, whose blog has published a list of five applications for better working with it.
MacOSX users should like the Remember the Moof widget, which filters tasks by both lists and tags.
RTM Tool for Windows is a native Windows application that fully reveals all the benefits of Remember The Milk by setting tasks with expiration dates and tags. You can also set up global hotkeys as you like.
If you use the Thunderbird mailer with the Lightning calendar plugin, then try the RTM connector for Thunderbird, an excellent plugin that will add a task management system with full synchronization with RTM to your email client.
A little trick on how to add tasks using Launchy using sending tasks by e-mail to RTM.
We offer you an available manual about how to add Windows RTM to the desktop using the built-in Active Desktop function.